Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT

Granulocyte-colony stimulating factor may improve pregnancy outcome in patients with history of unexplained recurrent implantation failure: An RCT

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Background: Family of colony-stimulating factors (CSF) have an essential role on early cross talk between embryo and uterine endometrium.Objective: The aim of this study was to evaluate the effects of the single dose of Granulocyte-CSF (G-CSF) injection on clinical outcome of assisted reproductive technology cycle in patients with repeated implantation failures.Materials and Methods: This randomized control trial study was performed on 52 infertile women who referred to the clinic with the history of more than three previous In vitro fertilization/Intracytoplasmic PLANT STEROLS sperm injection-embryo transfer failures.

All patients were stimulated with standard long protocol.All embryos were transferred on day five in blastocyst stage in both groups.The treated group received 300 μg (0.

5 ml) recombinant human G-CSF subcutaneously which was injected 30 min before blastocyst embryo Wind spinner transfer.Results: There was not statistically significant differences in abortion rate in G-CSF and control group (p=0.09).

G-CSF treated group showed higher clinical pregnancy rate in comparison with control group (56.2% vs.40.

0%) but it was not statistically significant (p=0.09).Although live birth rate in G-CSF group was higher than control group (53.

1% vs.35.0%) but there wasn’t statistically significant difference in the overall live birth rate between the two groups (p=0.

10).G-CSF group had a twin pregnancies while in control group there was no twin pregnancy.Conclusion: Our result demonstrates the possibility that pregnancy outcome is better in women with repeated unexplained In vitro fertilization failure who are treated with G-CSF.